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Title (deu)
REVEAL – PrioR EVidencE for new triALs. Version 3.0, October 2025
Description (deu)
This guide is for clinical researchers who plan a new clinical trial and need to rapidly review the literature for prior trials in a systematic fashion. The results of this process can be used to (1) identify and characterise the knowledge gaps to justify a new trial (e.g., lack of evidence, concerns about research quality) and (2) inform the research question and methods of the new trial (e.g., outcome measurements, sample size calculation and practical conduct).
The guide follows a stepwise process with two main parts:
Part A describes a systematic search for and quality assessment of existing relevant systematic reviews on the topic of the planned trial. If a relevant, high-quality and up-to-date systematic review of previous trials answers the planned research question, no further trial is necessary. If the systematic review concludes that more evidence on the planned research question is needed, the new trial can be convincingly justified, and the available evidence can be used to inform the pro tocol and conduct of the new trial. If there is no relevant, high-quality and up-to-date systematic review, the researcher must continue with Part B.
Part B describes a systematic search for and quality assessment of relevant clinical trials on the topic. If there are no trials or only those that are methodologically compromised, or if too few pre vious trials exist to answer the planned research question, the new trial can again be convincingly justified.
This guide includes (1) a detailed guidance document (= the document that you are reading at the moment) listing for each step the essential and optional tasks with explanations and useful resources, and (2) a structured report form that takes researchers through the process step-by-step and provides a template to document all the relevant information needed to prepare respective sections of funding proposals or trial protocols for sub mission for ethics review:
doi.org/10.48341/reveal-reportform
In addition, there is (3) a worked example with a completed report form and sample text for a funding proposal or a trial protocol:
doi.org/10.48341/reveal-example
Keywords (eng)
clinical trialssystematic search
Type (eng)
Language
[eng]
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Date issued
2025-10-22
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https://door.donau-uni.ac.at/o:5764 - Other links and identifiers
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