https://door.donau-uni.ac.at/o:6045 World Stroke Organization: Global Stroke Fact Sheet 2025 Feigin, Valery L Valery L Feigin 0000-0002-6372-1740 Auckland University of Technology Brainin, Michael Michael Brainin 0000-0001-8363-4962 Universität für Weiterbildung Krems Norrving, Bo Bo Norrving Lund University Martins, Sheila O Sheila O Martins Universidade Federal do Rio Grande Pandian, Jeyaraj Jeyaraj Pandian 0000-0003-0028-1968 Christian Medical College Lindsay, Patrice Patrice Lindsay 0000-0002-2584-8580 Heart and Stroke Foundation F Grupper, Maria Maria F Grupper World Stroke Organization, Geneva, Switzerland Rautalin, Ilari Ilari Rautalin Auckland University of Technology SAGE Publications journal article eng Abstract Background: Among non-communicable disorders (NCDs), stroke remains the second leading cause of death and the third leading cause of death and disability combined (as expressed by disability-adjusted life-years lost—DALYs) in the world. Aims: The study was aimed to estimate global, regional and nationa burden of stroke and its risk factors from 1990 to 2021. Methods: Finding presented in this paper were derived mainly from the Global Burden of Disease 2021 Study on stroke burden published in The Lancet Neurology 2024:23:973-1003. Results: The estimated global cost of stroke is over US$890 billion (0.66% of the global GDP). From 1990 to 2021, the burden (in terms of the absolute number of cases) increased substantially (70.0% increase in incident strokes, 44.0% deaths from stroke, 86.0% prevalent strokes, and 32% DALYs), with the bulk of the global stroke burden (87.0% of deaths and 89.0% of DALYs) residing in lower-income and lower-middle-income countries (LMICs). Stroke attributable to metabolic risks constituted 69.0% of all strokes, environmental risks constituted 37.0%, and behavioral risks constituted 35.0%. Conclusion: This World Stroke Organization (WSO) Global Stroke Fact Sheet 2025 provides the most updated information that can be used to inform communication with all internal and external stakeholders; all statistics have been reviewed and approved for use by the WSO Executive Committee and leaders from the Global Burden of Disease research group. Stroke ransient ischemic attack statistics incidence prevalence mortality http://creativecommons.org/licenses/by-nc/4.0/ https://door.donau-uni.ac.at/api/object/o:6045/download 10.1177/17474930241308142 application/pdf International Journal of Stroke issn:1747-4930 International Journal of Stroke 20 2 132 144 708.90 kB 2025