Valery L Feigin Valery L Feigin Michael Brainin Michael Brainin Bo Norrving Bo Norrving Sheila O Martins Sheila O Martins Jeyaraj Pandian Jeyaraj Pandian Patrice Lindsay Patrice Lindsay Maria F Grupper (World Stroke Organization, Geneva, Switzerland) Maria F Grupper Ilari Rautalin Ilari Rautalin SAGE Publications 2025 Abstract Background: Among non-communicable disorders (NCDs), stroke remains the second leading cause of death and the third leading cause of death and disability combined (as expressed by disability-adjusted life-years lost—DALYs) in the world. Aims: The study was aimed to estimate global, regional and nationa burden of stroke and its risk factors from 1990 to 2021. Methods: Finding presented in this paper were derived mainly from the Global Burden of Disease 2021 Study on stroke burden published in The Lancet Neurology 2024:23:973-1003. Results: The estimated global cost of stroke is over US$890 billion (0.66% of the global GDP). From 1990 to 2021, the burden (in terms of the absolute number of cases) increased substantially (70.0% increase in incident strokes, 44.0% deaths from stroke, 86.0% prevalent strokes, and 32% DALYs), with the bulk of the global stroke burden (87.0% of deaths and 89.0% of DALYs) residing in lower-income and lower-middle-income countries (LMICs). Stroke attributable to metabolic risks constituted 69.0% of all strokes, environmental risks constituted 37.0%, and behavioral risks constituted 35.0%. Conclusion: This World Stroke Organization (WSO) Global Stroke Fact Sheet 2025 provides the most updated information that can be used to inform communication with all internal and external stakeholders; all statistics have been reviewed and approved for use by the WSO Executive Committee and leaders from the Global Burden of Disease research group. PDFDocument eng 2026-02-20T13:11:14.718533Z 2025 Stroke ransient ischemic attack statistics incidence prevalence mortality 725916 b application/pdf http://creativecommons.org/licenses/by-nc/4.0/